Meridian Bioscience Eliminates Cold Chain with the First Liquid Ambient Temperature Stable qPCR Master Mixes

CINCINNATI, Sept. 16, 2025 ~ Meridian Bioscience, Inc., a global leader in diagnostic testing solutions and life science raw materials, has made a groundbreaking announcement today. The company's Life Science division has launched the industry's first liquid qPCR master mixes that have been proven to remain stable for over 12 months at ambient temperatures. These mixes can also be shipped with oligos without compromising their performance, eliminating the need for refrigeration, freezing, or costly lyophilization.

This innovative breakthrough offers a level of flexibility and convenience that was previously unavailable in liquid formats. With superior performance, these new mixes expand Meridian's portfolio of ambient-stable molecular reagents while simplifying logistics, reducing costs, and delivering sustainable solutions for assay developers and high-throughput automation users across all settings.

For decades, the molecular diagnostics industry has faced challenges in preserving liquid reagents. The two primary methods used were maintaining a continuous cold chain or converting them into a dry format through processes like lyophilization. However, both methods added significant expenses, complexity, and potential points of failure to the supply chain.

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Meridian's new liquid formulations have been proven to maintain full performance after more than 12 months at ambient temperatures (15-25°C), with reliable results even after extended exposure to 50°C. This eliminates the need for cold-chain shipping and reduces the cost and potential delays associated with it. End-users in hospitals, reference labs, or point-of-care settings can now store the assays at room temperature with complete confidence in their performance.

The new ambient-stable liquid mixes are available in two formats: Liquid Stable Ready Mix (MDX364) and Liquid Stable Flex Mix (MDX360). The former is a qPCR master mix designed for manufacturers creating ready-to-use assays. It has been proven to maintain full functionality for over 12 months at ambient temperature and for over two weeks at 50°C even in the presence of oligos (primers and probes). This mix is ideal for high-throughput assay developers who are manufacturing assay kits for large-scale use, with primers and probes stabilized directly in the mix for a true ready-to-use format.

On the other hand, the Liquid Stable Flex Mix (MDX360) is a qPCR master mix that can be stored and shipped without a cold chain while maintaining full functionality for over 12 months. Primers and probes are added by the end-user at the point of use, offering maximum flexibility in assay design. This mix enables labs and developers running flexible formats to validate the mix against a broad menu of targets, while giving their customers the option to select and run specific targets at point of use, on demand.

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Florent Chang-Pi-Hin, Vice President of Research and Development at Meridian Life Science, stated that "the new master mixes give assay developers the flexibility to choose the format that best supports their workflow." He further added that "they can now design ready-to-use assays without the cost and risk of cold chain and lyophilization and empower their customers with tests that remain stable at ambient temperatures for ultimate convenience." Both options reduce labor, turnaround time, and error risk while making it easier to deliver scalable, automation-friendly assays even in decentralized or point-of-care settings.

Meridian's liquid-stable qPCR mixes have eliminated the need for cold chain and lyophilization, providing assay developers with new flexibility while cutting costs and simplifying logistics. By ensuring reliable performance at room temperature, these formats support faster, more scalable, and more sustainable diagnostics in any setting. For more information on Meridian's liquid ambient-stable qPCR DNA master mixes, please visit: https://www.meridianbioscience.com/liquid-ambie....

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